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线性化聚乙烯亚胺 Max PEI MAX 40000 生化试剂
简要描述:
线性化聚乙烯亚胺 Max(MW 40,000)PEI MAX 40000:是热卖产品线性化聚乙烯亚胺PEI25,000的升级产品,不同之处在于1)*水解(去乙酰化);
产品时间:2023-02-15
Polyethylenimine HCl MAX, Linear, Mw 40,000
线性化聚乙烯亚胺盐酸盐 MAX(PEI 40,000)
基本描述:
Polyethylenimine HCl MAX, Linear, Mw 40,000(PEI 40,000)是热卖产品线性化聚乙烯亚胺PEI25,000的升级产品,不同之处在于1)*水解(去乙酰化);2)PEI25,000的盐酸盐形式,具更高的水溶特性;3)含更长连续性乙烯亚胺(ethyleneimine)片段,其质子化氮水平比PEI25,000提高11%以上。本品经碱中和后,可转化为线性化自由胺(PEI),此时分子量正相当于25,000。
Thomas M,et al(2005)研究数据表明,去乙酰化的PEI 40,000(Polyethylenimine MAX 40,000)体外质粒DNA转染效率提高21倍,小鼠体内靶向效率达到10,000倍,随之肺部特异疗效显示增强1500倍。
化学性质:
CAS NO. | 9002-98-6, 26913-06-4 |
Molecular Weight | 40,000(~22,000 free base) |
Solubility | Soluble In: Cold and room temperature water Insoluble In: Common organic solvents (ethanol, acetone, tetrahydrofuran) |
Appearance | White to off-white free flowing solid |
订购信息:【*,现货供应】
品牌 | 货号 | 名称 | 规格 | *(元) |
Polysciences | 24765-2 | 线性聚乙烯亚胺盐酸盐Max,(MW 40,000) (Equivalent to Mw 25,000 in Free Base Form) | 2g | 咨询 |
另,提供基本型PEI 25,000。 | ||||
Polysciences | 23966-2 | 线性聚乙烯亚胺(MW 25,000) | 2g | 咨询 |
应用文献【基因转染用途】 :
Mann JF, McKay PF, Arokiasamy S, Pa RK, Klein K, Shattock RJ. (2013). Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection. J Control Release. 170(3):452-9.
Thomas M, Lu JJ, Ge Q, Zhang C, Chen J, Klibanov AM. (2005). Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci U S A. 102(16):5679-84.
——Written/Edited by V. Shallan【版权归MKBio懋康所有】
线性化聚乙烯亚胺 Max(MW 40,000)PEI MAX 40000
线性化聚乙烯亚胺 Max(MW 40,000)PEI MAX 40000